It did not come entirely as a surprise when Ms Katherine Chong’s third child, Lim Si Jia, was diagnosed with glycogen storage disease eight years ago, when she was eight.
Si Jia’s brother, who is two years older, also developed the disorder when he was around the same age.
Ms Chong’s elder daughter, 21, is the only one of her children who does not have the disease.
“Every parent would be very sad,” said Ms Chong, 52, who works in the insurance sector.
“But there is a reason for everything, and we had to accept the reality.”
The genetic condition is estimated to affect one in every 100,000 people globally.
Si Jia, like her brother, would eventually have to get a liver transplant to stay alive.
Her brother received a new liver from a brain-dead patient last year.